After you mission warped, run to the Simpsons House jump on the bush to enter the Simpsons house instead of running to the door.
A good piece of tech to know is when you exit your car to talk to Flanders hold a direction so Homer don't close the car door behind him. This allows to remove the opening door animation and Homer will quickly enter the car which is faster than jumping on it. Here's an example:

After talking to Barney go on your left and get gas stations coins.

If you feel confident you can go to the right of the tree which saves a small amount of time.

Make sure to park away from the grass to not despawn Family Sedan after completing the mission which saves a few seconds.

Flicking Cameras

These are some flicking cameras you can use to have better traffic to deal with.

Drive back to the Simpsons House.
A good piece of tech to know is when you exit your car to talk to Flanders hold a direction so Homer don't close the car door behind him. This allows to remove the opening door animation and Homer will quickly enter the car which is faster than jumping on it. Here's an example:

After talking to Barney go on your left and get gas stations coins.

If you feel confident you can go to the right of the tree which saves a small amount of time.

Make sure to park away from the grass to not despawn Family Sedan after completing the mission which saves a few seconds.

Flicking Cameras

These are some flicking cameras you can use to have better traffic to deal with.

After you mission warped, run to the Simpsons House jump on the bush to enter the Simpsons house instead of running to the door.
Because this is Any% you don't need to get in your car so just run to Flanders.

The fastest route involves two Timeskips: One at Wiggums

And another one for Flanders backyard

If you don't want to deal with any Timeskips just get Wiggums in this mission and get Flanders in 1-5.

After you mission warped, run to the Simpsons House jump on the bush to enter the Simpsons house instead of running to the door.

After you mission warped, run to the Simpsons House jump on the bush to enter the Simpsons house instead of running to the door.
A good piece of tech to know is when you exit your car to talk to Flanders hold a direction so Homer don't close the car door behind him. This allows to remove the opening door animation and Homer will quickly enter the car which is faster than jumping on it. Here's an example:

After talking to Barney go on your left and get gas stations coins.

If you feel confident you can go to the right of the tree which saves a small amount of time.

Make sure to park away from the grass to not despawn Family Sedan after completing the mission which saves a few seconds.

Flicking Cameras

These are some flicking cameras you can use to have better traffic to deal with.

Nothing to note in this mission for NG+.